Abstract
Prostacyclin derivative (CS-570) with strong suppression on platelet aggregation was examined as an anticoagulant for haemodialysis. Thirty stable dialysis patients were dialyzed using this drug. CS-570, 50-150ng/kg/min, was continuously infused into the blood line with or without heparin. As a result, blood coagulation was effectively suppressed by the drug in the blood line. Haemodialysis is maintained by proper dose of CS-570 without adverse effect. These results strongly suggest that CS-570 is a promissing antiplatelet drug applicable to haemodialysis treatment.
