1987 Volume 16 Issue 2 Pages 1016-1022
We have experienced the LDL apheresis for the patient, 49 yrs old woman, of familial hypercholesterolemia (heterozygotes). The LDL apheresis was performed by the utilization of KNA-01 colum containing dextran sulfate which ability of selective adsorption for LDL. The clinical data was evaluated followir. 1 year experience. The concentration LDL was reduced about 70% following the LDL apheresis and this reduced amount was about 7.7g. The patient was well controlled serum cholesterol concentration within 250mg/ml. The biocompatibility was also evaluated with C3a, C5a and thromboxan B2. And these results indicated that there was no problem of utilization of KNA-01.
