Abstract
An on-line regeneration method for the artificial reticuloendothelial system (ARES) containing phenylalanine as a ligand was developed to improve the adsorption capacity of the adsorbent during plasma perfusion. The use of a 5% glucose soluticn could elute the adsorbed rheumatoid factor, imnunoglobulins and complements from the used adsorbent in vitro. A patient with rheumatoid arthritis was treated with the regeneration method of ARES. During plasma perfusion, ARES was regenerated usually twice with 1 liter of a 5% glucose solution. After each regeneration, the adsorption capacity of ARES was demonstrated to be improved by determining the pre-and postcolum plasma levels of rheumatoid factor. Joint pain improved markedly, grasping strength increased and ability to walk improved after the treatment of the patient with the regenerative artificial reticuloendothelial system (PARES).
