Evaluation of ability in protein permeable filter

Abstract

It is well known that some severe complications on regular dialysis patients-retractory anemia, bone disease, and dialysis amyloidosis etc- are so difficult to cure by conventional dialysis. Recently effective results of the complications are reported by using protein permeable filter. We tested five different membrane filter about UFR, low molecule clearance, large molecule clearance and adhesive protein to membrane surface. Reduction rate of UFR were much larger than that by conventional dialyzer. Large molecule clearance was so larger than that by conventional one. In all filter adhesion of protein were seen on the surface. We examined to remove adhesive protein by using Triton X-100. The results showed that in PMMA adhesive protein, especially β₂-MG was the largest among all membrane. The reason why a large amount of β₂-MG adherented to PMMA membrane is not clear but further study is needed to clarify this membrane charateristic.