1987 Volume 16 Issue 2 Pages 830-833
Plasma leucotrien (LT) B4 and C4/D4 levels were evaluated during various blood purification methods. Although fasting LT concentrations of regular hemodialysis (HD) patients were not different from those of normal controls, LTs increased gradually during HD, in which LTs at the outlet of dialyzers were higher than those at the inlet. The elevation of LTs was more remarkable in HD with regenerated cellulose than that with PMMA or new cellulose membrane which had little effects on complement system. More significant increase in LTs was noted in direct hemoperfusion with activated charcoal. In hemofiltration, only venous LTs increased at the end of therapy concomitantly with the concentration polarization of the membrane. LTs showed little changes during plasmapheresis, however same concentration of LTs as systemic blood was noted in the separated plasma. These results indicate that the alteration of plasma LTs might be determined by membrane materials and/or modes of treatment. LTs appear to be useful indices to evaluate the blood compatibility of blood purification methods.
