KINETICS OF MANGANESE TRANSPORT IN CHRONIC HEMODIALYSIS PATIENTS

Abstract

Manganese (Mn) transport and dialysance during hemodialysis were examined in fifteen chronic hemodialysis patients. Serum Mn levels in fifteen volunteer outpatients tended to increase after 5-hour dialysis; (0.20±0.06μg/dl before HD; 0.25±0.06 after HD). Serum Mn levels were 0.64±0.12μg/dl in normal subjects. The increase was mainly due to hemoconcentration evidenced by a significant increase in the hematocrit during HD. To study the changes resulting from diffusion, we measured Mn in the arterial blood and in the dialysate at the inflow and outflow sites of the dialyzer. Mn diffused across the dialyzer from the blood to the dialysate in fifteen cases. Mn dialysance of 15 patients was-48.6±71.7ml/min. The relationship between ultrafiltrable Mn levels and serum Mn levels before HD was a significant correlation (r=0.69, p<0.005).