RELATION BETWEEN BLOOD AND CSE IN RENAL FAILURE

-DIALYSIS DISEQUILIBRIUM SYNDOROME AND BRAIN DEATH-

Abstract

Arterial blood (B) and CSF (C) of hemodialysis (HD) patients were obtained and analysed to investigate dialysis disegailibrium syndrome (DDS). B-BUN was decreased more significantly compared to C-BUN during HD. As a result, this caused the folowing condition: B-Osm<C-Osm. B-pH was increased but C-pH was almost constant. These two differences in pH and Osm between B and C were thought to be related to DDS. Although B-K, B-Ca and B-P were changed greatly, the changes of C-K, C-Ca and C-P were very small. This stability of CSF were recognized in a case with cerebral bleeding and continued for two days after brain death. The low concentration and smaller change of C-Cr, compared to B-Cr, probably indicate that Cr has more toxicity than BUN.