Abstract
A blood modulation system has been developed for use in artificial liver support system using polyetherurethane sheet embedded with powderd charcoal (UPC) prepared mainly for the purpose of effectively adsorbing protein-bound and middle-molecular substances. This system consist of a UPC-plasmaperfusion (using recirculation system) followed by a supplementary of about 1l plasmaexchange using hemodialysis for the purpose of performing both removal and supplementary therapy at the same time. In the clinical application, the amounts of bilirubin and bile acids removed by UPC-plasmaperfusion reached 40%. This removal amounts of bilirubin and bile acids may be equivalent to 55% and 70% of that of plasmaexchange, respectively.
