Abstract
The oral adsorbent (AST-120) is a fine spherical shaped activated carbon for oral use. In the present study, this adsorbent was administered to clarify its effect on surgically induced hepatic failures, and blood metabolites were analysed by multi-column HPLC system. Fifteen dogs underwent porta-caval anastomoses and 70% hepatectomies, and divided into two groups, AST group and control group. Dogs in the AST group received the oral adsorbent intermittently with diet. Blood ammonia and bile acids were increased in the control group. Blood middle molecular weight substances were increased in the control group. These middle molecular weight substances were adsorbed by this adsorbent in in-vitro study.
