Daily Glycemic Control of Human Diabetics by Closed-loop SC Insulin Infusion

Abstract

Closed-loop sc insulin infusion algorithm was applied to control daily glycemic excursion in diabetics. By changing the control parameters during postprandial period, glycemic control was compatible to that with closed-loop iv infusion. The subcutaneous insulin pharmacokinetic model well simulated the pattern of plasma free insulin from sc infused insulin profile. The new algorithm for closed-loop insulin infusion was developed which calculated infusion rate to compensate the deficit of insulin dose in sc space.