1987 Volume 16 Issue 2 Pages 995-998
An anti-tumor activities of endotoxin immobilized fiber (LPS-F) was measured by Vx2 tumor of rabbits using hemoperfusion (DHP). In place of viable Bacillus Calmette Guerin (BCG), OK-432 was injected intravenously as a priming agent. DHP using the carrier fiber of LPS-F (sham DHP) was examined as a control study. The effects of multiple treatment of DHP using LPS-F was also studied. Priming agent of OK-432 only did not influence Vx2 tumor growth. DHP suppressed the tumor growth significantly against the those of DIP (-) and sham DHP. And survival day of DHP group also ploronged significantly. Multiple and early DHP treatment were more effetive.
