Abstract
Open heart surgery has been widely performed with aids of heart and lung machine. At this time, heparin has been routinely used as an anticoagulant drug during extracorporeal circulation (ECC), But, there are some problems concerning to the control of platelet aggregation and vasodilation. This study is to evaluate and improve antithrombogenicity during and after ECC. From these standpoints of view, changes of platelet counts and the value of β-Thromboglobulin with or without administration of Gabexate mesilate (FOY) were precisely observed during and after ECC. And the values of TXB2 and 6 Keto PGF1α which are stable substances produced from TXA2 and PGI2 were also evaluated to get the changes of antithrombogenicity during ECC. Subsequently, a marked changes of antithrombogenicity could be obtained. That is, remarkable decrease of platelet counts and increase of β-TG were disclosed. Besides, an increase of TXB2 and a decrease of 6 keto PGF1α were clearly recognized during ECC. For the purpose to correct these abnormal changes, FOY or PGE1 were given in 55 cases with cardiac disease, and satisfactory results could be obtained. In conclusion, on the basis of these findings these drugs as well as PGI2 analogue (OP-41483) should be adequetly given for control of platelet aggregation or vasodilation in addition to administration of heparin.
