Abstract
The antithrombogenicity of segmented nylon610 based on nylon610 and poly (propylene oxide) was studied. These materials have a microstructure composed of crystalline and amorphous phases. The antithrombogenicity was analyzed by simulating thrombus formation in vitro and the patency of implanted tubing as arteriovenous shunt in vivo. It was found that the copolymer having a crystallite thickness of 6.5nm and a long period of approximately 12nm suppressed the activation of adhering platelets on the surface to exhibit excellent antithrombogenicity. This paper suggests the importance of regulating crystalline-amorphous microstructure for the antithrombogenicity of polymer surface with semicrystalline state.
