Abstract
In case of high performance membrane (HPM), there are some difficulties in evaluating the characteristics by conventional method of hemodi alysi s membrane because of the peculiarity of HPM. The difference between UFR taken by water and bovine blood varies depending on each HPM. Therefore, blood should be used for the evaluation of HPM. Because of higher UFR of HPM, the filtration at the inlet of module and the backfiltration at the outlet will occure even if the UFR is adjusted to be 0. In evaluating the clearance of low molecules, filtration should be taken into consideration as well as the diffusion. We developed a new method using the mixture of concentrated SCUM solution from the patient and bovine blood for the evaluation of β2-MG sieving in vitro. The data by this method shows a good correlation with the clinical data. This method is usable and applicable to the evaluation of HPM.
