Abstract
The removal performance and mechanism of β2M were studied with a new PAN dialyzer (ASAHI PAN 12CX2) both in vitro and in vivo. Sieving coefficients (SC) for β2M and for albumin were found to be 0.6 and 0.002, respectively. Adsorption of β2M was observed only in early stage of dialysis. The diffusive part of β2M clearance was evaluated as 27.3ml/min at QB=200ml/min and estimated to be as much as two-third of total β2M clearance even in 9 liter substituted HDF. The backfiltrating effect in β2M clearance was calculated to be less than 10% of total clearance for HD without filtration. In vivo removal ratio of β2M were 48.8% for hemodialysis and 55.6% for 6 liter substituted HDF and these results were in good accordance with the in vitro estimation. These results indicate that new PAN dialyzer possesses high removal capacity for β2M, and the elimination by diffusion is a major contributing factor for the removal.
