Abstract
Kinetic analysis of β2-microglobulin (β2-MG) was made in vivo and in vitro studies among three dialyzers with different potency on complement activation. Plasma β2-MG was significantly increased at the end of dialysis using cuprophan or PMMA (β2) membrane dialyzer, but significant reduction was noticed in EVAL membrane dialysis. Complement activation dose not seem to be involved, because less activation was observed in PMMA membrane dialyzer than others. β2-MG synthesis on cultured peripheral mononuclear cells revealed that extracorporeai recirculation itself increased β2-MG synthesis with no relation to dialyzer membrane and sterilyzation method. Kinetic study showed that mean distribution volume of β2-MG was 27.6% of body weight which was larger than intravascular volume and that prodaction rate was 0.129mg/hr/Kg.
