Abstract
With long survival of patients on hemodialysis, accumuration of non-or poorly dialyzable solutes has resulted in severe complications. On-line HDF (hard HDF) was performed to remove as large amount of B2-MG as possible. With use of High performance membrane (HPM) as hemodiafilter and bicarbonate dialysate ultrafiltrated by PMMA filter as substitution fluid, hard HDF was applied for 6 patients. In condition of QB: 200-300, QD: 500ml/min, QF: 4000-5000ml/hour, Total exchage volume: 15-20L/session and HPM: F60 (polysulfone) or H12-3000s (PAN, AN 69), following results were obtained. Total elimination of B2-MG per sessin and reduction rate of B2-MG ranged 150-300mg, 50-70%, respectively. Maintenance level of B2-MG could be lowered by 10-20mg/L (about 30%).
In conlusion, maximum removal of B2-MG up to 1g/week may be possible with HPM and on-line system.
