Abstract
Antiadhesive pericardium with heparin slow release was newly develcped. Fresh porcine pericardium was soaked in distilled water and sonicated in order to cause cell destruction. In this way, a natural tissue membrane composed of collagen was obtained. The membrane was crosslinked by a hydrophilic epoxy compound instead of glutaraldehyde to maintain the natural tissue elasticity and hydrophilicity, and heparinized ionically using protamine as a binding site. Heparin prevents the precipitation of fibrin, which leads to cellulofibrous adhesive tissue. Therefore, the membrane with heparin slow release can prevent the adhesion in its early stage. Animal experiment revealed that the membrane had excellent antiadhesive property. The pericardium in the long term experiment was covered with a layex of mesothelial cells which has a natural and permanent antiadhesive property.
