Abstract
Two types of rate responsive pacemaker available in a fever were fabricated and tested in animal experiments. One type was a temperature-sensitive pacemaker (TSP) which detected right atrial blood temperature. And, another one was a respiratory rate-sensitive pacemaker (RSP) which counted the rate with a respiratory pick-up put around the chest wall. After the administration of pyrogenic drug, 2-4-Dinitrophenol, oxygen consumption promptly elevated, and the blood temperature slowly rose, and the respiratory rate initially also increased. TSP continued the elevation of pacing rate by the metabolic accelaration, and kept the cardiac output increasing, but, there was a considerable time lag between the oxygen consumption increasing and the pacing rate elevation. RSP promptly increased the packing rate with the metabolic elevation, but, it did not continued the rate increasing, and sometimes decreased the rate and the cardiac output in spite of the oxygen consumption increasing.
