Abstract
Effects of heparin bonded artificial membrane lung and circuit on blood coagulation were invsstigated in prolonged extracorporeal lung assist of goats. A veno-venous bypass ECLA was performed in twelve goats up to ten days. Six of them (group I) were with heparin bonded device and the other six (group II) were with the usual device. In group I, heparin was continuously infused at a rate of 17 unit/kg/hr to maintaine the activated coagulation time at around 130 seconds, while in group II 30unit/kg/hr of heparin was necessary to maintain ACT at about 200 seconds to prevent blood coagulation in the bypass circuit. Number of platelet decreased significantly in group I (by 40% of pre ECLA value) as well as group II, but aggregation activity was higher than in group II. Fibrinopeptide A and antithrombin III and other coagulation factors showed no significant difference between two groups. Autopsy showed no major pathological findings. ECLA with heparin bonded surface provided excellent blood compartibility and required only a little systemic heparin administration. The heparin bonded bypass circuit will enable ECLA even in hemorrahgic patients.
