Abstract
6 Mongrel dogs were anesthetized and intubated. After muscular paralysis induced by pancronium, extracorporeal circulation (ECC) was initiated under apneic CPAP, i. e. 100% O2, 10cm H2O airway pressure. Oxygenation was maintained by transalveolar oxygen diffusion, while CO2 was converted to bicarbonate by the systemic infusion of trihydroxymethylamino methane (THAM); generated bicarbonate was removed by hemodialysis. Blood flow rate of ECC was 15ml/kg/min. Volume of CO2 removed from blood was about 30ml/dl during ECC. This method caused depletion of bicarbonate, and infusion of THAM was required.
