Abstract
This study investigates the clinical evaluation of the relationships, using γ-GT, β2-m and Ccr, between the urine volume during extracorporeal circulation (ECC) using the membrane oxygenator and post operative renal function. Thirty patients were devided into three groups according to urine volume (UV) during ECC: Group I, 7 patients, UV<5ml/min, Group II, 8 patients, 5<UV<10ml/min, Group III, 15 patients 10ml/min<UV. γ-GT levels had a pattern of change similar to that of β2-m. I group demonstrated higher levels of γ-GT and significantly slower recovery of Ccr as compared with II, III groups. This study showed the γ-GT was a good marker of tubular function, and in order to maintain the renal function, it was thought to be very important to secure the UV levels at least over 10ml/min from the early stage of ECC.
