Abstract
The changes of platelet count, plasma βTG and PF4 concentrations and other hematological parameters were analyzed in order to evaluate the effect of 2ng/ml/min of Iloprost infusion on platelet preservation during CPB. 13 patients were divided into 2 groups. Group I: control (5 cases). Group II: Iloprost (8 cases). Iloprost infusion did not inhibit the platelet activation due to heparin administration, however, 20μM ADP-induced aggregation was significantly suppressed and platelet loss was prevented during CPB in Group 2. The increase of plasma levels of βTG and PF4 during CPB was significantly suppressed in Group 2 as well. It is concluded that Iloprost infusion is effective to preserve platelet during CPB.
