PRELIMINARY REPORT ON PHARMACOKINETICS AND DIALYZABILITY OF UFT GIVEN TO PATIENTS WITH CHRONIC RENAL FAILURE ON HEMODIALYSIS

Abstract

In our experience, 4.0% of the patients with chronic renal fuilure on haemodialysis were complicated by malignancy, and in some cases, chemotherapy was indicated. However, available data concerning the administrative protochol of antineoplastic agents to these patients seem limited at present. This time we paid attention to UFT and conducted some preliminary experiments on pharmacokinetics and dialyzability of this antineoplastic agent. The results suggest that, in spite of the possible binding to albumin, this agent can be removed almost exclusively from the plasma when 5 hour haemodialysis is completed provided that an appropriate dialyzer, QB, QD etc were chosen.