1989 Volume 18 Issue 3 Pages 1252-1255
The measurement of myoglobin (Mb), CPK and guanidino compounds in the serum of 98 patients with chronic renal failure, half of them were treated with hemodialysis, was carried out to investigate the influence of guanidino compounds on muscle metabolism. The result showed that there was significant correlationship between Mb and CPK, and less apparent correlationship between Mb and creatinine. However, any relationship was not found between Mb and β2-MG, and also between Mb and methylguanidine. The serum Mb concentration decreased after PPHDF, was increased again with time until next PPHDF. Moreover, the level of serum Mb elevated gradually with long term treatment of PPHDF. This phenomena suggested that muscle metabolism might be affected by PPHDF, which induced hypoalbuminemia.
