Abstract
The in vivo and in vitro tissue regeneration of artificial grafts were discussed from a biomaterial point of view. The emphasis was placed on the interplay of homo-and hetero-cell communities. The self-regenerated extracellular matrices and secreted humoral factors (cell growth factors and angiogenesis factors) primarily determine the tissue remodeling and tissue neovascularization. The current biomaterial technology serves as matrices for cell adhesion and growth. Surface design concept of enhancing more, bioactive role in tissue engineering was discussed. Prototype models of artificial basement membranes and extracellular matrices were presented.
