Abstract
An approach to develo ement of the ideal vascular prostheses; evaluation of anti-thrombogenesityand elastic properties of a small cal fiver segmented polyurethane graft.: Despite improvements of the vascular prostheses, the need for small caliver vascular prostheses remains unfulfilled. To improve the patency of small cal fiver grafts, the imporance of compliance in vascular graft design and anti-thrombogenecity are emphasized. In this study, new type segmented polyurethane grafts 3mm in diameter, which have the same compliance as human arteries and strong anti-thrombogenesity, were implanted in mongrel dogs and anti-thrombqgenecity and elastic properties of the grafts were evaluated by 111In platelet scintigraphy and laser compliance measuring system respectively. Platelet scintigraphy showed the same anti-thromboensity in this graft as in EPTFE graft and the patency rate 3 months after implantation was 50 percent. Compliance of the grafts was maintained favorably after implamtation and there was no significant differenceof stiffness-parameter β between control group and implanted group. This new type graft seems to have a good patency to replace small diameter arteres in the coronary and peripheral circulations.
