IN VIVO EVALUATION OF ANTITHROMBOGENICITY FOR ION IMPLANTED SILICONE USING In-111-TROPOLONE-PLATELETS

Abstract

H⁺, N₂⁺ and O₂⁺ ion implantations in silicone were performed at 150keV to improve antithrombogenicity. The antithrombogenicity was tested by the superior vena cava (SVC) indwelling method, using In-111-tropolone-platelets. The accumulation of platelets onto H⁺ implanted specimen and that of O₂⁺ implanted specimen and SVC decreased. The formation of functional groups induced by ion implantation depended on the ion species employed. The decrease in accumulation of platelets was related to new functional groups.