DEVELOPMENT OF SURFACE MODIFICATION TECHNOLOGY AND ITS APPLICATION TO TWO-DIMENSIONAL CULTURED CELL PATTERN

Abstract

In this paper, a novel surface patterning technology of cultured cells was developed. Based on photoreactive chemistry coupled with UV-irradiation, patterning of hydrophilic or hydrophobic surface characteristics were easily manipulated by using a photomask with a fine pattern. The irradiated surfaces after casting of photoreactive hydrophilic polymer resulted in chemical fixation. No adhesion of endothelial cells on treated surface and adhesion/grouwth on non-treated surfaces successfully formed two-dimensional patterning of cultured cells.