DEVELOPMENT OF SURFACE MODIFICATION TECHNOLOGY BASED ON PHOTOREACTIVE CHEMISTRY AND ITS APPLICATION TO SURFACE MODIFICATION OF FABRICATED DEVICES

Abstract

A novel surface modification technology using photoreactive phenyl azide was developed especially to provide biocompatibility of surfaces of fabricated devices. Hydrophilic poly (dimethyl acrylamide) copolymer having phenyl azide groups were synthesized and cast on polymeric films. UV-irradiation resulted in chemical fixation of hydrophilic polymer on surfaces. A marked reduced cell adhesion (platelets and endothelial cells) were achieved, indicating that the technology developed here may find a potential application of surface modification of fabricated devices.