1990 Volume 19 Issue 3 Pages 1207-1210
(i) Uniform sinu-soidally fluctuating (50-800 s-1) shear rates were applied to canine blood which was contained in the concavo-convex Couette-flow test system, and evaluation of thrombus formation was derived from the clotting ratio (determined from the rate of increase of frictional torque between two cones). (ii) The relation between thrombus formation (clot in the pump & emboli in the kidney) and the flow-rate was examined in left ventricular bypass animal (goat) tests with pneumatically driven pulsatile pump for 3-35 days. The results show that clotting ratio decreases when the time of application of lower (<100 s-1) shear rate is modified by intermittent application of higher (>500 s-1) shear rates.
