PREPARATION AND BIOCOMPATIBILITY EVALUATION, OF POLYURETHANES

Abstract

Polyurethanes used in artificial organs still need further modification in their biocompatibility and stability in vivo. Polyurethanes consisting of different types of diisocyanate, soft segment and chain extender were prepared and evaluated for their biocompatibility by a cell culture method. New types of polyurethanes having perfluorooctanesulfonamide group, hydroxyl group, polydimethylsiloxane segment and polythiodiethanol segment were prepared and showed various response to Ca. 9. 22 cells. Introduction of hydrophobic unit such as perfluoro group and polydimethylsiloxane segment was effective to reduce cell attachment.