1990 Volume 19 Issue 3 Pages 1231-1234
Hemorrhage of an injured solid organ is very difficult to control. Although many new materials and instruments have been developed for repair and hemostasis, they are not, as yet, totally satisfactoly. Recently Matsuda et al had developed a series of novel elastomeric surgical adhesives based on a hydrophilic urethane prepolymer (PUP-134, 201). We used this material to achieve hemostasis of internal bleeding in the dog & rat. Animals were anesthetized, surgically explored, and solid organs were cut. The surface of traumatized area was compressed with a sheet of teflon or silicon, which was painted with a very thin layer of PUP-134 and 201, for about 2 minutes, and then removed. This material adhered very well and preventing any bleeding.
Gross and histological studies (24hrs to one year) revealed a mild degree of inflammatory reaction in the earlier stage. After one year, tissue healing was almost complete. It had been confirmed the safety of PUP-201 by skin patch test, subcutaneus and intrperitoneal injection.
