A RAPID-HEALED VASCULAR PROSTHESIS WITH A NON-PERMEABLE INNER COAT

Abstract

Tissue ingrowth into graft wall is the creeping from anestomesis sites as well as the infiltration from outer layer around a graft. In this report, we introduce a rapid-healing vascular graft with inner coating. The grafts were implanted in thoracic aortae of dogs. The cells infiltrated more rapidly into inner coated grafts rather than non coated grafts. It was observed from our in vitro study that fibroblasts were less active in serum. All of these evidences suggested that the healing process around a graft was enhanced by preventing the leakage of serum components. So we design a new type of vascular graft with an inner coat of biodegradable polymer, which results in quiker healing.