DESIGNED OF NEW UNTITHROMBOGENETIC MATERIAL

Abstract

Polystyrene derivatives having various sugar moiety was synthesized.In this study, the interaction between platelet and polymers was estimated. From the various evidence such as percentage of platelet adhesion, shape change, it is certified that these polymers have theexellent ability to suppress platelet adhesion and activation. From the study of the amount of polymer adsorption, it was shown that, these abilities were revealed only when the density of coated polymers was high. Since these polymers can be adsorbed on lots of hydrophobic surfaces, we can easily obtain non active surfaces to platelet. It may be expected that the polymer is applied to various artificial organs and medical devices.