Abstract
We treated end-stage renal failure patients with intermittent short-time push/pull HDF (P/P HDF) while at the same time using a wearable artificial kidney for continuous arterio-venous hemofiltration (CAVH) in between the P/P HDF treatments. During the short-time P/P HDF treatments we transfered dialysate comparable to 3% body weight into the body through membrane, and this amount was removed during the CAVH treatment following the P/P HDF therapy. Thus, the hemodynamics was stabilized during the P/P HDF treatment and, despite the fact that there was no water restriction, the body weight during the times in which P/P HDF was not performed remained in the virtually dry condition. The Kt/Vurea during the combination treatments was equivalent to that with regular dialysis treatment. The time-averaged β2-microglobulin concentration in the course of this period of the combination treatment was found to be significantly lower than during conventional regular dialysis treatment period.
