Abstract
We examined the adsorptive characteristics of highly performed membranes for hormones regulating blood pressure, namely, AVP and endothelin. Membranes used in the experiment were cuprophan (SP1. OH), PMMA (BK1. OU), polysulfone (F50), EVAL (KF 201-1000) and PAN (Filtral). During an in vitro study using bovine serum, AVP was strongly adsorbed by the PMMA membrane and the PAN membrane and slightly adsorbed by the polysulfone membrane and the EVAL membrane, but not by the cuprophan membrane. The AVP adsortive rate of the PAN membrane was greater than that of the PMMA membrane. In addition, the β2-MG adsorptive rate of the PAN membrane was smaller than that of the PMMA membrane. On the other hand, endothelin was not adsorbed by each membrane. These results indicate that the adsorption of the hormone in the dialysis membrane depends on the specificities of the hormone and the characteristics of the membrane.
