EXPERIMENTAL EVALUATION OF THE ANTITHROMBOGENICITY OF NEW HEPARINIZED POLYURETHANE BIOMATERIAL

Abstract

The antithrombogenicity of newly developed heparinized polyurethane(H-PU) coated PVC tube was evaluated by 4hrs temporary A-A bypass in 5 dogs. With the limited shear rate(24.8+5/sec), the H-PU coated PVC tubes exhibited significantly less morphologic change of adhered plateletes in SEM finding compared with pellethane(PU) coated PVC tubes(n=6) and uncoated PVC tubes(n=6). And, it had shown only little spotted thrombus deposited in the four H-PU coated PVC tubes and no thrombus in one. The result of ACT and heparin concentration during bypass within three groups revealed there might be no release of heparin from the new H-PU coated tubes. In conclusion, this study indicated that the new H-PU coated PVC tube probably offered excel-lent antithrombogenicity at the low shunt blood flow.