Abstract
A new heparinization method has been developed to obtain anti-thrombogenic polymers of which anti-thrombogenicity is based on the pharmaceutical effect of heparin. Heparinized polyurethane(H-Pu) was synthesized with this new method, then its anti-thrombogenicity along with the study of behaviors of the heparin in the material was evaluated. At first, several polymerizable cationic surfactants which have a methacrylate group are synthesized. These monomers yield noble complexes which are soluble in some organic solvents to make sonically equivalent bonding with the heparin. Using one of these complexes derived from the quaternary vinyl monomers and heparin, radical polymerization with hydrophilic co-monomer is carried out in dimethylformamide. The Lee-White test revealed an excellent anti-thrombogenicity of the H-Pu. Furthermore, the study of mechanisms of the anti-thrombogenicity using a chromogenic and a prothrombin time method has made it clear that the property is attributed to the effect of retained heparin on the surface of the H-Pu, not of the released one.
