Abstract
This paper reports development of a solution-castable polymer which can chemically bind proteins. Vinyl copolymers with activated ester groups in side chains were obtained from radical copolymerization of N-acryloxysuccinimide(AOSu) with styrene(ST). The ESCA measurement showed that surface enrichment of ST was observed at lower content of AOSu. However, at higher content of AOSu, anisotropic effect on surface chemical composition was much reduced. The fibronectin-bound surface was found to be cell-adhesive, whereas albumin-bound surface was non-adhesive. Little desorption and exchange of proteins on surfaces were observed for chemically fixed proteins, which was in a marked contrast with those of physically adsorped proteins.
