Abstract
The effect of haptoglobin for renal failure was evaluated in patients undergoing open-heart surgery. The patients with hemoglobinuria after extracorporeal circulation were divided into 2 groups; the control (Group C, N=10) not treated with haptoglobin, and the haptoglobin (Group H, N=12) treated. The urinary levels of α1-m were significantly higher in Group C than in Group H. The urinary levels of β2-m in Group H were less than 10, 000g/l for 7 POD, while those in Group C were still high at the 3rd POD. The urinary levels of α1-m and β2-m remained low from the 1st POD in the Group H. Haptoglobin is effective for renal failure after open-heart surgery.
