Abstract
The predictor of mean aortic or left atrial pressure (mAoP or mLAP) under LVAD driving was investigated in acute animal experiments. The relationship between mAoP (or mLAP) and mean bypass flow (mBF) was assessed by using a time-series model. Based on these data, the parameters for prediction of mAoP or mLAP for given mBF were determined. The predictor was applied to mongrel dogs with LVAD. Vacuum pressure of LVAD was changed every 30-60 beats, then LVAD was stopped. The changes of mAoP, mLAP and mBF were recorded. Using the data in the period of LVAD-on, mAoP or mLAP in no BF was predicted and these values were compared with the measured values in LVAD-off state. The differences in mLAP were under 1mmHg in most cases. There were a few cases that mAoP followed the change of mBF in the experiments. Prediction of mAoP with these data showed the differences few mmHg. The predictor was feasible for prediction of mLAP and mAoP for given BF. The predicated pressures may be useful information to control LVAD. And the predicted value in no BF can be used as a simple indicator for the weaning of LVAD.
