EFFECT OF NEW MODULE DESIGN OF DIALYZER MADE OF POLYACRYLONITILE (PAN) MEMBRANE

Abstract

The effect of module design on in vitro clearance of highly permeable polyacrylonitrile (PAN) dialyzer was studied. This membrane (PAN DX) has large pores to have a good solute permeability. Type A is a conventional dialyzer in which the packing ratio of hollow fiber is 60%. Type B has higher packing ratio (66.5%), and the spacer filaments which are dispersed among hollow fibers in order to improve the uniformity of dialysate flow. X-ray CT method shows that dialysate flows more uniformly in type B dialyzer. Higher values in vitroβ₂-MG and dextran (Mw=10, 900 and 38, 000) clearance are obtained in the type B dialyzer than the type A dialyzer without the spacer filaments.