Abstract
We invented the dialyzer with gentle protuberance around the inlet of a hollow fiber membrane of which surface was smoothed. Observation of flow in blood port using a dye clarified that occurrence of vortex was inhibited and retention time of blood was about a half in our dialyzer header as compared with a conventional header. Extracorporeal circulation of mongrel dogs without heparin, using a conventional header became impossible by blood clotting after 45 minutes. On the contrary, pressure drop by the dialyzer with a new header was 114±33mmHg even after two hours of circuration. Moreover almost nochange of plat 1 et counts allowed us to confirm that the blood flow and antithrombogenecity were improved in this header.
