Abstract
In order to clarify the effect of a newly developed PEG grafted cellulose membrane dialyzer (PEG) on coagulation-fibrinolysis and endothelial cell stimulation, a controlled cross-over study was done concering the increased ratio during HD in plasma thrombin-ATIII complex (TAT), fibrinopeptide A (FPA), FOP (D-dimer), alpha 2-PI-plasmin complex (PIC), tissue plasminogen activator (t-PA) and von Willebrand factor (vWF)(a marker of stimulation to endothelial cells) comparing PEG with dialyzers of three other membranes, i. e., regenerated cellulose(OC), PMMA (P), and cellulose diacetate (CD). TAT increased during HD but the increment was significantly lower in PEG than in OC. Both FPA and FDP (D-dieter) increased during HD and the increments were similar in the four different membranes. PIC significantly increased during HD in all four membrane but the increment of PIC was significantly less in PEG than in three other membranes (DC, P, CD). Changes in t-PA during HD were similar to those in PIC, vWF significantly increased during HD but increasd to a significantly less extent in PEG than in OC, P and CD. These results indicate that PEG shows less enhancements in coagulation-fibrinolysis and endothelial stimulation during HD than the others, suggesting that PEG may attenuate the recurrent damage to endothelial cells during HD.
