Abstract
Continuous hemodialysis (CHD) is accepted as alternative method for conventional hemodialysis for treating acute renal failure in patients with multiple organ failure associated with unstable hemodynamics. Plasma levels of fibrinopeptide A (FPA), fibrinopeptide Bβ15-42 (FPB β15-42), thrombin/anti-thrombin III complex (TAT) and FDP-D-dimer were determined in 6 patients with hypercoagulative and fibrinolytic disorders during CHD. Nafamostat mesilate was administered for anticoagulation at 10-20mg/hr. These values of parameters descrived in the above decreased at 6 or 12 hours after the start of CHD, at 24 hours, regained to high initial levels. The FPA/FPB β15-42 ratios obtained after 12 hours suggested an activation of coagulation system. In these instances, it is reasonable to assume that coagulation was stimulated in patients at 24 hours after the start of CHD. These results indicate that the mesurements of these parameters are useful to the timely exchange of hemodialyser and to the determination of the amount of anticoagulants.
