THE EVALUATION OF BLOOD COMPONENTS DEPOSITION ON NEWRANES OF CELLULHE, POLYETHYLENE GLYCOL (PEG GRAFTE7) CELLULHE, CELLULOSE DIACETATE AND POLYMEIIIYL METHACRYLATE

Abstract

Blood components deposition on various membranes including cellulose (OC), new PEG grafted cellulose (PC), cellulose diacetate (CDA) and polymethyl methacrylate(PMMA) were investigated after hemodialysis. The amount of adsorbed proteins were the most prominent in PMMA (10.38 ±1.67μg/cm²), while CDA 0.495±1.27, μ/cm²), and PC (6.50±2.61μg/cm²) were small. The amount of adsorbed LDH were the smallest in PC (3.33±3.05×10_-4U/cm²) and the largest in PMMA (49.36±17.53×10_-4U/cm²). Analysis of adsorbed protein by SHE-PAGE method showed different among the membranes. The band of high moleculer weight was small and that of alubumin was large in PC compared with CDA and P4 A. PC had the least blood components deposition among four membranes detected by scanning electron microscopy. It is considered that these results may contribute to the anti-thrombogenicity on PC membrane.