Abstract
Prostaglandin E1 (PGE1) has known to improve renal and peripheral circulation in shock state. We estimated the perioperative renal function and peripheral blood flow in 30 cardiac surgical patients (pts) with or without PGE1 during cardiopulmonary bypass (CPB). 15 pts were administered 0.05-0.2μg/kg/min of PGE1 during CPB (group PG) and other 15 pts served as control (group C). Age, CPB time and aortic clamping time showed no statistical difference between two groups. In both groups no one seemed to have advanced to renal failure considering from Cr and Ccr value. But perioperative sodium excretion ratio (FENa), free water clearance (CH2O), urine β2-microglobulin (UBMG) and urine NAG showed significant increase indicating perioperative renal tubular dysfunction. In group PG, significantly lower FENa and CH2O at CPB than group C, lower UBMG at 1 postoperative day (1POD) and lower NAG at both 5 POD and 7 POD were observed. Peripheral blood flow during CPB decreased significantly compared to pre CPB in group C but not in group PG. Administration of PGE1 during CPB wad suggested to improve subclinical renal tubular dysfunction and impaired peripheral circulation caused by CPB
