Abstract
EPPD was developed to enhance peritoneal mass transport. Four dogs were anethetized and received PD which consisted of 2-hour control PD with 1L dialysate and EPPD as follows: 1L of dialysate was instilled intraperitoneally and a bag which contained 1000ml dialysate was connected to the retained Tenckhoff catheter. The bag was pulsated by an electric massager with vibration at either 150 or 1440 cycles/min. Dialysance of urea, creatinine and inulin were measured as well as ultrafiltration rate (UFR) and lymphatic absorption. UFR increased by 142% and dialysance by 23-95%. The latter increased more prominently as the molelular size increased and the frequency of vibration increased. An increase in peritoneal blood flow may partly contribute to an increase in dialysance and a decrease in peritoneal lymphatic flow to an increase in UFR.
