THE DEVELOPMENT OF SUBCUTANEOUS INSULIN INFUSION ALGORITHM FOR WEARABLE ARTIFICIAL ENDOCRINE PANCREAS USING RAPID ACTING INSULIN ANALOGUE

Abstract

For long-term clinical application of the wearable artificial endocrine pancreas, closed-loop subcutaneous insulin infusion algorithm has been developed by analyzing the kinetics of subcutaneous absorption of Lys (B28)-Pro (B29) Human Insulin Analogue which was absorbed 2 to 3 times faster after subcutaneous injection than usual short-acting insulin. A 3-compartmental model was applied to mathematically express the relation between the insulin injected subcutaneously as an input and the plasma insulin response as an output. With this algorithm, glycemic levels were controlled without hyperglycemia nor hypoglycemia after oral glucose loads to pancreatectomized dogs. These data indicated feasibility of long-term glycemic control in diabetic patients with closed-loop subcutaneous insulin infusion by the wearable artificial endocrine pancreas.